SYNTHESIS, CRYSTAL STRUCTURE, HIRSHFELD SURFACE ANALYSIS, MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES OF NOVEL OLANZAPINIUM 2,5-DIHYDROXYBENZOATE AS POTENTIAL AND ACTIVE ANTIPSYCHOTIC COMPOUND

The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2,5-dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of olanzapinium 2,5-dihydroxybenzoate crystalline salt.The structure of the compound was characterized by 1H-NMR, 13C-NMR, and single-crystal X-ray diffraction analysis.The Hirshfeld an

Recently, topological data analysis has become a trending topic in data science and engineering.However, the key technique CURRANT CHOCO of topological data analysis, i.e., persistent homology, is defined on point cloud data, which does not work directly for data on manifolds.Although earlier evolutionary de Rham-Hodge theory deals with data on man

Recently, the coexistence of ultra-reliable and Bronc Flank Strap low-latency communication (URLLC) and enhanced mobile broadband (eMBB) services on the same licensed spectrum has gained a lot of attention from both academia and industry.However, the coexistence of these services is not trivial due to the diverse multiple access protocols, contrast

Substantial evidence supports the use of either clozapine or cognitive-behaviour therapy (CBT) for refractory symptoms of psychosis, and are recommended in many national guidelines.However, the two treatments have not been directly compared in a head-to-head trial.The aim of this study is to estimate the proportion of clients with refractory sympto